Objective: To investigate the clinical efficacy of Professor Fang Heqians prescription

Jiangzhi decoction (JZD) in treatment of hyperlipidemia. Method: One hundred and eighty patients with hyperlipidemia were randomly divided into treatment group

Xuezhikang group and simvastatin group (n=60 each). The treatment group was treated with JZD (granules)

once daily; patients in Xuezhikang group was given 2 grains bid orally; the patients in simvastatin group was given 20 mg orally per day. The treatment was lasted for 8 weeks. Lipid levels and phlegm-turbidity accumulation syndrome in Chinese medicine were investigated. Result: The total efficiency of the treatment group was 79.31%

Xuezhikang group was 71.92%

and 84.75% in the simvastatin group. No significant difference among the groups was found. The syndromes efficiency of the treatment group was 94.82%

better than 78.94% of Xuezhikang and 67.79% of simvastatin (P<0.05

P<0.01). Triglyceride (TG)

high density lipoprotein-cholesterol (HDL-C)

low density lipoprotein-cholesterol (LDL-C)

apolipoprotein A (ApoA)

apolipoprotein B (ApoB)

and ApoA/ApoB of the treatment group showed no significant difference compared with those in simvastatin group. The TC of the treatment was higher than the simvastatin group (P<0.05); the improvement of TC

HDL-C

LDL-C

ApoA of ApoA/ApoB of the treatment group was better than Xuezhikang group (P<0.05). Conclusion: JZD is promising in regulation of lipid metabolism with good clinical efficacy

and worthy for further study.