盐酸青藤碱聚乙烯醇微胶囊的制备及体外释放机制考察

窦鹏; 张华; 张雯

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盐酸青藤碱聚乙烯醇微胶囊的制备及体外释放机制考察

更新时间：2024-01-04

- 盐酸青藤碱聚乙烯醇微胶囊的制备及体外释放机制考察
- Optimization of Preparation Technology and Investigation of Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules
- 中国实验方剂学杂志 2012年18卷第24期页码：49-52
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- 纸质出版日期：2012
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窦鹏, 张华, 张雯. 盐酸青藤碱聚乙烯醇微胶囊的制备及体外释放机制考察[J]. 中国实验方剂学杂志, 2012,18(24):49-52.

DOU Peng, ZHANG Hua, ZHANG Wen. Optimization of Preparation Technology and Investigation of Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 49-52.
窦鹏, 张华, 张雯. 盐酸青藤碱聚乙烯醇微胶囊的制备及体外释放机制考察[J]. 中国实验方剂学杂志, 2012,18(24):49-52. DOI：

DOU Peng, ZHANG Hua, ZHANG Wen. Optimization of Preparation Technology and Investigation of Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 49-52. DOI：

摘要

目的: 优选盐酸青藤碱聚乙烯醇(SM-PVA)微胶囊的制备工艺

并考察其表征及体外释放性能。方法: 以载药量为指标

选取乳化剂用量、搅拌速度、戊二醛体积分数及油相环己烷用量为考察因素

采用W/O/W复乳界面聚合法制备SM-PVA微胶囊

通过正交试验优选SM-PVA微胶囊的制备工艺;采用紫外分光光度法测定载药量

扫描电镜观察SM-PVA微胶囊形貌

粒径分析仪表征胶囊粒径分布情况

同时考察SM-PVA微胶囊的体外释放性能。结果: 优选的制备工艺为乳化剂用量7%

搅拌速度600 r·min-1

戊二醛用量25%

环己烷10 mL

载药量6.23%;制备的SM-PVA微胶囊平均粒径约16 μm

呈均匀分散、表面光滑的球形。制得的SM-PVA微胶囊在模拟胃液和肠液中都表现出较好的缓释作用。结论: SM-PVA微胶囊可成为中药盐酸青藤碱的一种新型给药系统。

Abstract

Objective:To optimization preparation technology of sinomenine hydrochloride-polyvinyl alcohol (SM-PVA) microcapsules

and investigate its characterization and in vitro release performance. Method: With drug loading as index

the amount of emulsifier

stirring speed

volume fraction of glutaraldehyde and dosage of cyclohexane(oil phase) were chosen as factor

SM-PVA microcapsules was prepared byW/O/W multiple emulsion interfacial polymerization method

preparation technology of SM-PVA microcapsules was optimized by orthogonal test;drug loading was determined by UV spectrophotometric

morphology of SM-PVA microcapsules was scanned by electron microscopy

particle size of SM-PVA microcapsules was charactered by particle size analysis instrument

and in vitro release performance was investigated. Result: Optimum preparation technology was:7% emulsifier

stirring speed 600 r·min-1

volume fraction of glutaraldehyde 10 mLand 25% cyclohexane

drug loading 6.23%;Average particle size of SM-PVA microcapsules 16 μm

it showed uniform dispersion and smooth surface of spherical.These prepared SM-PVA microcapsules showed good sustained release in simulated gastric and intestinal fluid. Conclusion: SM-PVA microcapsules could be a novel drug delivery system of sinomenine hydrochloride from Chinese materia medica.

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