Objective:To investigate the changes of vascular endothelial function in patients with non-alcoholic fatty liver disease(NAFLD) and the intervention of Silybin Capsule. Method:Sixty patients with NAFLD were selected and randomly divided into 2 groups

routine group (n=30) was treated with vitamin E capsules(100 mg

tid); the Bailing Capsule group (n=30) was treated with Silybin Capsule(105 mg

tid). Another 30 healthy patients as control group. After 3 months treatment

the endothelium-dependent flow-mediated dilatation(FMD) of brachial artery was determined with ultrasound

and the levels of body mass index(BMI)

alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

cholesterol (TC)

triglyceride (TG)

high density lipoprotein-cholesterol (HDL-C)

low density lipoprotein-cholesterol (LDL-C)

high sensitivity C-reactive protein (hs-CRP)

free fatty acids(FFA)

insulin resistance index (HOMA-IR)and endothelin-1(ET-1) in three groups were measured respectively before and after treatment. Result:All patients with NAFLD showed that the BMI

ALT

AST

TC

TG

LDL-C

hs-CRP

HOMA-IR

FFA and ET-1levels were higher thantheseof the controlled group(P＜0.05)

the HDL-C and FMD levels were lower than those of the controlled group(P＜0.05). After treatment the hs-CRP

HOMA-IR

FFA

ET-1 level in the Silybin Capsule group·L-1

HOMA-IR (3.34±0.58)

FFA (0.52±0.21)mmol·L-1

ET-1(98.7±10.6) ng·L-1] was decreased more significantly than routine group·L-1

(3.62±0.74)

(0.68±0.16)mmol·L-1

(160.5±11.78) ng·L-1] (P＜0.05). After treatment the FMD in the Silybin capsule group was increased more significantly than routine group (P＜0.05). Conclusion:The Silybin Capsule can effectively reduce the body's insulin resistance

inflammationrecovery and recovery vascular endothelial function in patients with NAFLD.