Objective:To study the effects of Naomai Shukang capsule on transient ischemic attack in mice. Method: Kunming mice were divided into Naomai Shukang capsule group (1.8

0.9

0.45 g·kg-1)

the model group

sham operation control group

and the positive control group (Xueshuantong 1.125 g·kg-1

nimodipine 0.03 g·kg-1)

mice were fed Naomai Shukang capsule for 7 d

on the 8 d

after 1 h of administration

both sides of the common carotid artery were ligatured for 30 min and reperfusion for 15 min to make transien cerebral ischemia model; superoxide dismutase(SOD)and malonaldehyde(MDA) content were determinated; section of brain tissue was homogenated

Na+-K+-adenosine triphosphatase(ATPase)

Mg2+-ATPase

Ca2+-Mg2+-ATP

Ca2+-ATPase activity of brain homogenate were measured

part of brain tissue was calculated after weighing for brain water content. Result: Naomai Shukang capsule could enhance Na+-K+-ATPase

Mg2+-ATPase

Ca2+-Mg2+-ATP

Ca2+-ATPase activity in brain

and decrease MDA content

increase SOD activity

brain edema was relieve induced by cerebral ischemia. Conclusion: Naomai Shukang capsule can improve ATP energy of brain

scaveng oxygen free radicals

relieve cerebral edema

protect brain cells

reduce brain structure and function damage.