满山红总黄酮-PEG 6000固体分散体的制备及体外溶出度考察

孔艳; 尹蓉莉; 李开; 张立; 朱双燕; 陈柳钦

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满山红总黄酮-PEG 6000固体分散体的制备及体外溶出度考察

更新时间：2024-01-04

- 满山红总黄酮-PEG 6000固体分散体的制备及体外溶出度考察
- Investigation of Preparation and Dissolution of Total Flavonoids from -PEG 6000 Solid Dispersion
- 中国实验方剂学杂志 2013年19卷第4期页码：62-64
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- 纸质出版日期：2013
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孔艳, 尹蓉莉, 李开, 等. 满山红总黄酮-PEG 6000固体分散体的制备及体外溶出度考察[J]. 中国实验方剂学杂志, 2013,19(4):62-64.

KONG Yan, YIN Rong-li, LI Kai, et al. Investigation of Preparation and Dissolution of Total Flavonoids from -PEG 6000 Solid Dispersion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 62-64.
孔艳, 尹蓉莉, 李开, 等. 满山红总黄酮-PEG 6000固体分散体的制备及体外溶出度考察[J]. 中国实验方剂学杂志, 2013,19(4):62-64. DOI：

KONG Yan, YIN Rong-li, LI Kai, et al. Investigation of Preparation and Dissolution of Total Flavonoids from -PEG 6000 Solid Dispersion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 62-64. DOI：

摘要

目的: 制备满山红总黄酮-聚乙二醇6000(PEG 6000)固体分散体

并考察其体外溶出度。方法: 以PEG6000为载体

采用溶剂-熔融法制备3种不同比例的固体分散体

紫外分光光度法(以芦丁计)测定总黄酮含量

考察各固体分散体的体外溶出特性。结果: 原料药在60 min内的累积释放度57.032%;满山红总黄酮-PEG6000 1:2

1:4

1:6的固体分散体于60 min的累积释放度分别为80.21%

91.43%

74.32%。结论: 溶剂-熔融法制得的各比例固体分散体均能显著提高药物的溶出速率。

Abstract

Objective: To prepare total flavonoids from Rhododendron dauricum-PEG 6000 solid dispersion

and investigate its in vitro dissolution. Method: With PEG6000 as carrier

three different proportion of solid dispersion was prepaerd by dissolvent-fusion method

the content of total flavonoids was determined by ultraviolet spectrophotometry method

and in vitro dissolution was studied. Result: Cumulative release of bulk drugs within 60 min was 57.032%;Cumulative release of 1: 2

1: 4

1: 6(total flavonoids from R. dauricum-PEG 6000) solid dispersion within 60 min was 80.21%

91.43%

74.32%

respectively. Conclusion: Each proportion solid dispersions could significantly improve dissolution rate of drug

which were prepared by dissolvent-fusion method.

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