Objective: To optimize extraction technology of Impatiens balsamina by central composite design/response surface methodology. Method: With ethanol concentration

extraction time and solvent ratio as independent variables

yield of total flavonoids from I. balsamina as dependent variable

levels of independent variables were regressed by multiple linear and fitted by binomial

response surface method was used to optimize extraction process

and prediction analysis was carried out by comparing observed and predicted values. Result: Optimal extraction technology was as following:extracted 164.08 min with 23.83 times the amount of 81.55% ethanol

deviation between observed and predicted values was-1.08%

multiple correlation coefficient of binomial fitting model was 0.987 1. Conclusion: This optimized extraction process of I. balsamina was simple with high precision and good predictability.