Objective: To investigate the prevention and treatment effects of Qinggan Lishi Jiejiu decoction on rats with alcoholic fatty liver(AFL). Method: Male SD rats were randomly divided into 2 groups:normal group and model group. Rats were administered with alcohol and fed with high fat diet including FeSO4 to replicate AFL model. All model rats were divided into model group

the compound Yiganling group (0.042 g·kg-1

) and the Qinggan Lishi Jiejiu decoction group (10

20

40 g·kg-1). While molding

the normal group and the model group were administered saline

the other groups were given corresponding medicine by gavage for 6 weeks. After giving medicine for 6 weeks

we measured the following indexes:weight; liver index; levels of triglyceride(TG)

total cholesterol(TC)

low-density lipoprotein cholesterol(LDL-C)

high-density lipoprotein cholesterol(HDL-C)

aspartate aminotransferase (AST)

alanine aminotransferase(ALT)

glutamyltranspeptidase(GGT) in serum; malondial dehyde(MDA)

superoxide dismutase(SOD) in serum and hepatic tissue. Result: Compared with the model group

in the Qinggan Lishi Jiejiu decoction middle dose group and high dose group

the following indexes were significantly decreased:liver index were (3.18±0.42)

(3.13±0.38)%

the contents of TG were (1.09±0.20)

(1.04±0.14)mmol·L-1

the contents of TC were (1.54±0.14)

(1.51±0.21)mmol·L-1

the contents of LDL-C were (0.15±0.02)

(0.14±0.01)mmol·L-1

the contents of AST were (194.10±16.43)

(171.50±11.40)U·L-1

the contents of ALT were (57.70±5.62)

(50.80±3.52)U·L-1

the contents of GGT were (2.80±0.40)

(1.80±0.40) U·L-1 in serum

the contents of MDA were (6.50±1.32)

(4.70±1.05)μmol·L-1 in serum and (3.07±0.72)

(2.07±0.65)nmol·mg-1 in hepatic tissue; the following indexes were significantly increased:body weights were (316.47±29.47)

(320.71±32.04)g

the contents of HDL-C were (0.55±0.07)

(0.56±0.07)mmol·L-1 in serum

the contents of SOD were (43.67±2.38)

(48.00±1.56)U·mg-1 in serum and (57.31±3.12)

(60.67±1.97)U·mL-1 in hepatic tissue. All the experimental data had statistieal significance(P<0.05

P<0.01). Conclusion: Qinggan Lishi Jiejiu decoction can significantly improve liver function

decrease blood lipid and peroxidation

enhance antioxidant capacity.