Objective:To investigate the clinical curative effect of the heart-spleen deficiency insomnia by split Guipi soup according to thepathogenesis. Method: Sixty patients suffering from heart-spleen deficiency type of insomnia were randomly divided into treatment group and control group. The treatment group was given split soups from Guipi soup

namely"wu fang" and "mei fang"

in the morning and before going to bed accordingly. The control group was given Guipi soup. The duration of treatment lasted 2 weeks. Patients of both groups were measured before and after treatment by the clinical curative effects

Pittsburgh sleep quality index (PSQI) and mESS. Result: After treatment

the clinical curative effects of the two groups were similar

the improvement of the sleep quality in the treatment group was superior to that of the control group

with statistical difference (P<0.05). Conclusion: The split prescription according to insomnia pathogenesis could gain better clinical efficacy compared to simple syndrome differentiation.