Objective: To observe the influence of Buyang Huanwu decoction on endothelin(ET) and calcitonin gene-related peptide(CGRP) in patients with migraine. Method: Seventy two patients with migraine were divided into 2 groups randomly

36 patients in western medicine group were treated by Nimodipine tablets 20-40 mg once

3 times a day

To add ergotamine caffeine 1-2 tablets once in acute seizure phase.36 patients in Chinese medicine group were treated by Buyang Huanwu decoction

take a decoction a day

divided into morning and evening. Patients had received continuous treatment for three months.Migraine frequency

duration

severity

adverse drug reactions and the concentration of plasma CGRP and ET were monitored before and after treatment.And comparative study with 36 cases of normal. Result: The total efficiency of traditional Chinese medicine group was significantly higher than that of the western medicine group(P<0.05);ET in patients with migraine was significantly higher than those of normal people(all P<0.01)

CGRP in patients with migraine was significantly lower than those of normal people(all P<0.01);ET concentration

migraine scores were significantly lower and CGRP concentration were significantly increased patients than before treatment(all P<0.01);However

the role of traditional Chinese medicine group is more obvious than the western medicine group(all P<0.01);Buyang Huanwu decoction has no significant adverse reactions. Conclusion: Buyang Huanwu decoction eliminate migraine by regulate vasoactive substances CGRP

ET level and improve the condition of abnormal systolic and diastolic blood vessels.