Objective:To observe the antioxidation and anti-inflammation effect of genistein (Gen) on rat myocardial hypertrophy caused by isopropylarterenol (Iso). Method:The rat myocardial hypertrophy model was reproduced through hypodermic injection which lasted 10 days at back skin with Iso

1 mg·kg-1·d-1. Once the model was succesfully made

rats were administrated with corresponding doses of Gen

DMSO or normal saline through hypodermic injection from the second day

and the process lasted 14 days. After the last administration

the rats were lasted overnight and samples of blood and heart were collected under anesthesia status. The indexes of left ventricle were calculated

the activity of superoxide dismutase(SOD)

myeloperoxidase(MPO) and the concentration of malondialdehyde(MDA) in serum were detected

and interleukin-2(IL-2) in myocardial tissue was investigated with radioimmunity kits. Result:In model group

there was a marked increase in the left ventricle index

the activity of SOD in the serum was markedly decreased

the content of MDA and the activity of MPO in the serum were increased

the level of IL-2 in myocardial tissue of rats was increased. Treatment with Gen significantly increased the activity of SOD in the serum

decreased the content of MDA and the activity of MPO in the serum

reduced the level of IL-2 in myocardial tissue. Conclusion:Gen has antioxidation and anti-inflammation effect on the myocardial hypertrophy caused by Iso.