Objective:To observe clinical curative effect of Kang'ai injection combined with FLO chemotherapy regimen for advanced gastric cancer. Method: According to case inclusion criteria

80 patients with advanced gastric cancer were randomly divided into observation group and control group

40 cases in each. Two groups were treated with FLO regimen: 5-fluorouracil 2 600 mg·m-2 +500 mL intravenous saline infusion

d1-8; calcium folinate 200 mg·m-2+500 mL intravenous saline infusion

d1-8; oxaliplatin 85 mg·m-2+500 mL intravenous saline infusion

d1-8. The observation group was given Kang'ai injection intravenous infusion of 40 mL·d-1

d1-14

every 3 weeks for a cycle

2 consecutive cycles at least

then followed with the evaluation of the clinical efficacy

adverse reactions and living quality. Result: The total effective rate was 57.50% in the observation group

25% in control group

and the two groups showed significant difference (P<0.05). The two groups showed neutropenia

thrombocytopenia

anemia

nausea and vomiting

abnormal liver function

renal function abnormalities

peripheral neurotoxicity

hair loss and other side effects

but the control group toxicity reaction rate was higher than that in the observation group

with significant difference statistically (P<0.05). The quality of life in observation group was improved significantly compared with that in the control group (P<0.05)

the increasing rate of karmovsky performance statas(KPS) score was 70% in the observation group

while 37.5% in control group; the declining rate of KPS score was 5% in the observation group

while 22.5% in the control group. These changes in KPS score in the two groups were statistically significant. Conclusion: Kang’ai injection combined with FLO chemotherapy in treatment of advanced gastric cancer shows good clinical curative effect

less side effects

and improved quality of life.