Objective:To optimize the processing technology of Hanshuishi and obtain the basic pharmacodynamic parameters. Method: An orthogonal experiment of four factors and three levels was conducted to evaluate the Hanshuishi processing technology

and the characters of calcined products and CaCO3 content were used as observation indexes. The animals were divided into model group

100 mg·kg-1 Ranitidine group

360.4 mg·kg-1Jiebai Wan group

334.3 mg·kg-1the Jiebai Wan removed Hanshuishi group

26.1 mg·kg-1 henan Hanshuishi

zejiang Hanshuishi and xinjiang Hanshuishi groups

Pylorus-ligated rat model was applied to observe the effect on gastric juice volume

acidity and pH value of the rats subjected to intragastric administration. Result: The processed traits of Hanshuishi were crisp

white color and powder. The optimum conditions of the Hanshuishi were particle size of powder (20 mesh)

temperature of 1 000℃

time 1.5 h; In addition to the 13th sample produced in Zhejiang

the other Hanshuishi groups and the Jiebai Wan group removed Hanshuishi could significantly decrease the volume

total acidity and 1 h acid excretion of gastric juice of experimental rats and increase pH value; Except of increasing the pH value

Jiebai Wan group had no effect

The efficacy of henan Hanshuishi was optimal and the Zejiang one had a poor performance. Conclusion: Hanshuishi inhibited gastric secretion of rats; moreover

the efficacy of Hanshuishi from different areas has slightly different.