Objective: To optimize extraction and precipitation technology conditions of Liuyueqing polysaccharide capsule. Method: With the content of polysaccharide as index

orthogonal test was adopted to investigate influence of solid-liquid ratio

decoction times and decoction time on extraction technology of Liuyueqing polysaccharide capsule;With the content and yield of polysaccharide as comprehensive evaluation index

alcohol precipitation time and times

the amount of ethanol and alcohol precipitation concentration were chosen as factors

alcohol precipitation technology was optimized by orthogonal test.The content of total polysaccharides was determined by phenol-concentrated sulfuric acid method. Result: Optimal extraction technology of Liuyueqing polysaccharide capsule was as follows:decocted three times with 10-fold water

2 hours each time.Optimum alcohol precipitation conditions were:filtered extraction liquid

mixed and concentrated to 0.5 g ·mL-1

and then precipitated one time with 7-fold 95% ethanol for 12 hours.Under these conditions

purity of polysaccharide was up to 71.05%

yield of it was 6.83%. Conclusion: This optimized extraction and precipitation procedure was proved to be stable and reliable

it could provide experimental basis for Liuyueqing polysaccharide capsule.