Objective: To observe the effect of Shenfu Yixin granule on circular and myocardial angiotensin Ⅱ(Ang Ⅱ)level in chronic heart failure rats. Method: One hundred and fifty heathly male SD rats were randomly divided into sham-operated group(n=5) and model group(n=130).In model group the left anterior descending coronary artery was occluded

in sham operation group the sutures were passed under the left anterior descending coronary artery without ligation. After 8 weeks the modeling group was randomly assigned to 5 groups (n=10 in each group) based on the value of left ventricular eijection fraction(LVEF)<50% obtained by Color Doppler Ultrasound

such as Captopril group

Losartan group

two groups of Shenfu Yixin granule(5.5

21.9 g·kg-1)

model group. All the medicine was given through gavage once a day for 4 weeks

the rats in model group and sham operation group (n=10) were ig administered with equivalent sodium chloride once a day for 4 weeks. After 4 weeks LVEF was recorded with Color Doppler Ultrasound;the aortaventralis blood and cardiac muscular tissue were collected to detect index. Result: The LVEF was improved markedly in Shenfu Yixin granule(21.9 g·kg-1) group. Two Shenfu Yixin granule groups obviously decrease circular and myocardial angiotensin Ⅱlevel

the function was similar to Captopril. Conclusion: Shenfu Yixin granule can improve cardiac function in chronic heart failure(CHF) rats

decrease circular and myocardial angiotensin Ⅱleve to block renin angiotensin system(RAS)

maybe delay or improve cardiac remodeling.