Objective:To prepare acylated derivatives of mangiferin

and then to evaluate their anti-inflammatory activity. Method: Mangiferin was respectively reacted with acetic anhydride

propionic anhydride and butyric anhydride to produce acylated-derivatives. Swelling of mice ear and permeability of mice celiac capillary were used to evaluate the anti-inflammatory activity. Result: 3 compounds were confirmed: (a) 7

2'

3'

4'

6'-penta-acetyl-mangiferin(PAM)

(b) 3

6

7

2'

3'

4'

6'-hepta-propionyl-mangiferin(HPM)

(c) 3

6

7

2'

3'

4'-hexa-butyryl-mangiferin(HBM). Mangiferin's high and medium dose group (1.0

0.5 mmol·kg-1)

PAM's high and medium dose group (0.25

0.125 mmol·kg-1)

HPM's high

medium and low dose group (0.25

0.125

0.063 mmol·kg-1) and HBM's high

medium and low dose group (0.25

0.125

0.063 mmol·kg-1) could significantly inhibit the ear swelling and permeability of celiac capillary in mice

showing obvious anti-inflammatory effect. Conclusion: PAM

HPM and HBM were novel compounds and were reported for the first time.Acylated derivatives have stronger anti-inflammatory activity than their parent compound mangiferin.