Objective: To observe the effect of Tongfeng Shuning tablet (TST) on hyperuricemia in mice. Method: TST (1.1

2.2

4.4 g·kg-1) and allopurinol tablet (40 mg·kg-1) were given ig.for 7 d in mice. Hyperuricemia model in mice was established by uric acid (UA)

and UA in serum was determined. TST (0.75

1.50

3.00 g·kg-1) and allopurinol tablet (20 mg·kg-1) were given ig.for 7 d in rats

meanwhile

hyperuricemia in rats was established by adenine and ethambutol. UA

blood urea nitrogen (BUN) and creatinine (Cre) in serum were determined

kidney weight index and histopathological changes were also observed. Result: Compared with the mice model UA[(310.50±74.88) μmol·L-1]

UA levels in middle and high doses of TST were [(124.00±57.33)

(56.27±42.24) μmol·L-1](P<0.05

P<0.01). The UA level in high dose of TST was 86.10±32.09 μmol·L-1 lower than that (137.70±43.21 μmol·L-1)of the rat model (P<0.05). The level of Cre in middle and high dose of TST were [(45.80±8.46)

(48.50±6.80) μmol·L-1]

lower than that [(59.60±13.53) μmol·L-1] in the rat model(P<0.05

P<0.05). All doses of TST could decrease the kidney weight index(P<0.05

P<0.05

P<0.05) and relieve kidney histopathological damage(P<0.05

P<0.01

P<0.01).Conclusion: TST had significant effect on hyperuricemia.