Objective:To optimize extraction and purification technology of Evodia rutaecarpa. Method: With tranfer rate of evodine

evodiamine and rutacarpine as comprehensive evaluation index

influence of extraction times

solvent multiples

solvent concentration and extraction time on alcohol extraction technology of E. rutaecarpa was investigated by orthogonal test;With the mass fraction of evodine

evodiamine and rutacarpine as indexes

single factor test was used to investigate progressive water precipitation purification technology of extraction solution. Result: Optimum extraction technology was as following:refluxing extracted 3 times with 16 times the amount of 70% ethanol

3 hours each time;optimum progressive water precipitation purification technology:recovery of ethanol

centrifugation

precipitate was ultrasonic extracted 15 min with 20 times the amount of 90% ethanol

centrifugation

taking the supernatant

added quarter times of water in second time of water precipitation. Conclusion: Optimized extraction and purification technology could ensure effective components from E. rutaecarpa to maximize retention.