Objective: To investigate the protective effects of compound Nepeta angustifolia on myocardial ischemia/reperfusion-induced injury(I/R) in rats. Method: Sixty SD rats were divided into 6 groups randomly:sham group(onlyneddle not ligation)

model group

positive group(compound danshen tablets

1.08 g·kg-1)

N. angustifolia groups low-does

medium-does and high-does group(2.9

5.8

11.6 g·kg-1).Rats were continuous gavaged for 7 days

the ligation/relaxat-ion of left anterior descending artery was used to establish acute ischemia/reperfusion model.meanwhile monitoringⅡECG

arrhythmia and infarcted zone. Result: Compared with control

I/R group increased the incidence of reperfusion arrhythmia

infarcted zone and growth of J point and ST-T wave(P<0.01). Compared with I/R group

N. angustifolia groups reduced the incidence of reperfusion arrhythmia;delaying arrhythmia time; shorten the arrhythmia duration;diminished infarcted zone;reduced the growth of J point and ST-T wave on ECG

also slowed the heart rate of rats(P<0.01

P<0.05). Conclusion: N. angustifolia can play a protective role in myocardial ischemia/reperfusion-induced injury

which maybe relate to that N. angustifolia can reduce the incidence of arrhythmia;diminish infarcted zone;reduce the growth of ST-T wave and J point.