Objective: To explore the antipyretic and anti-inflammatory effects of Tylophora ovata. Method: SD rats were divided into 5 groups randomly:physiological saline group

positive control group

the water extract of T. ovata low-dose group (6 g·kg-1)

middle-dose group (12 g·kg-1) and high-dose group (24 g·kg-1). The fever model with high temperature was established induced by yeast in rats

and the inflammatory model with foot edema was established by carrageenan in rats. The antipyretic and the anti-inflammatory effects of T. ovata were observed

the content of prostaglandin E2(PGE2) in paw tissue were tested by ultraviolet spectrophotometry. Result: Compared with the saline group

the water extract of T. ovata middle-dose group and high-dose group showed significant antipyretic activity in rats with high temperature induced by yeast (P<0.05)

and appeared significant anti-inflammatory activity in rats with foot edema induced by carrageenin (P<0.05). Conclusion: T. ovata had notable effects of antipyretic and anti-inflammatory

the anti-inflammatory mechanism might be related to inhibition of PGE2 biosynthesis.