Objective: To investigate the effects of Zhouluotong capsule (ZLT) on diabetic peripheral neuropathy (DPN) and advanced glycation end products (AGEs) and its receptor in mice. Method: Fourty KK/Upj-Ay mice were randomly divided into model

ZLT (6.85

3.43

1.71 g·kg-1). Another ten C57BL/6 mice were as control group. Mice were given intragastrically for 12 weeks. The general appearance

fasting blood-glucose (FBG) and glycosylated hemoglobin (HbA1c) were observed. Motor nerve conduction velocity (MNCV) was observed. Pathological changes of sciatic nerve were observed by light microscope and electron microscope. The content of AGEs was examined by fluorospectrophotometry. The expression of AGEs receptor (RAGE) was examined by Real Time PCR and Western blot. Result: ZLT could ameliorate the symptom of model mice. High-dose ZLT could decrease FBG and HbA1c(P<0.05

P<0.01). MNCV were increased(P<0.05

P<0.01)and pathological lesions were alleviated in ZLT group. The content of AGE were significantly decreased(P<0.05

P<0.01). The expression of RAGE mRNA and protein were significantly decreased(P<0.05

P<0.01). Conclusion: ZLT has protective effects on DPN of mice via suppressing the expression of AGE

RAGE.