鸡内金多糖对糖尿病高脂血症大鼠血脂、血糖及细胞免疫功能的影响

蒋长兴; 蒋顶云; 熊清平; 时晓娟; 李燕

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鸡内金多糖对糖尿病高脂血症大鼠血脂、血糖及细胞免疫功能的影响

更新时间：2024-01-04

- 鸡内金多糖对糖尿病高脂血症大鼠血脂、血糖及细胞免疫功能的影响
- Effect of Polysaccharides from Galli Gigerii Endothelium Corneum on Blood Lipid,Blood Glucose and Cellular Immune Function in Diabetes Mellitus Rats with Hyperlipidemia
- 中国实验方剂学杂志 2012年18卷第20期页码：255-258
- 作者机构：
- 作者简介：
- 基金信息：
  
  江苏省科技厅工业支撑项目(BE2009098);淮安市工业基金项目(HAG07066)
- DOI：
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- 纸质出版日期：2012
- 稿件说明：
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蒋长兴, 蒋顶云, 熊清平, 等. 鸡内金多糖对糖尿病高脂血症大鼠血脂、血糖及细胞免疫功能的影响[J]. 中国实验方剂学杂志, 2012,18(20):255-258.

JIANG Chang-xing, JIANG Din-yun, XIONG Qing-ping, et al. Effect of Polysaccharides from Galli Gigerii Endothelium Corneum on Blood Lipid,Blood Glucose and Cellular Immune Function in Diabetes Mellitus Rats with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 255-258.
蒋长兴, 蒋顶云, 熊清平, 等. 鸡内金多糖对糖尿病高脂血症大鼠血脂、血糖及细胞免疫功能的影响[J]. 中国实验方剂学杂志, 2012,18(20):255-258. DOI：

JIANG Chang-xing, JIANG Din-yun, XIONG Qing-ping, et al. Effect of Polysaccharides from Galli Gigerii Endothelium Corneum on Blood Lipid,Blood Glucose and Cellular Immune Function in Diabetes Mellitus Rats with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 255-258. DOI：

摘要

目的: 研究鸡内金多糖(PECG)对糖尿病高脂血症模型的影响。方法: 以高脂高糖饲料饲喂Wistar大鼠30 d后

腹腔注射链脲佐菌素

继续以高脂高糖饲料饲喂

并分别以80

20 mg·kg-1剂量的鸡内金多糖灌胃给药40 d

测定血清血脂和血糖水平

计算胸腺指数和脾脏指数

检测淋巴细胞增殖能力

考察PECG对大鼠血脂、血糖及免疫功能的影响。结果: PECG能显著降低糖尿病高脂血症大鼠总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C) 水平和空腹血糖浓度(P<0.05)

升高高密度脂蛋白胆固醇(HDL-C)、胸腺指数及脾指数(P<0.05)

高剂量组大鼠的淋巴细胞转化能力增强

刺激指数(SI)明显升高(P<0.05)。结论: PECG能有效降低糖尿病高脂血症大鼠血糖和血脂水平

并能改善其细胞免疫功能。

Abstract

Objective:To study the effects of Polysaccharides from Galli Gigerii Endothelium Corneum (PECG) on blood lipid

blood glucose and immune function in diabetes mellitus rats with hyperlipidemia. Method: Wistar rats were feed with the high fat and sugar feedfor 30 d

thenthe rats was injected with streptozotocin intraperitoneally

continue to feed with high fat and sugar feed

meanwhile

administered orallywith 80

20 mg·kg-1 dosages of PECG for 40 d. Blood lipid

blood glucose and immune function in rats of different groups was observed.The index thymus and spleen were calculated. Result: The levels of total cholesterol (TC)

triaglyceride (TG)

low density lipoprotein cholesterol (LDL-C) and blood glucose decreased significantly (P<0.05) and those of high density lipoprotein cholesterol (HDL-C)

the index thymus and spleen increased greatly(P<0.05) and SI increased obviously in rats of high dose PECG group (P<0.05). Conclusion: PECG can decrease the level of fasting blood lipid and blood glucose in diabetes mellitus rats with hyperlipidemiaand improved cellular immune function significantly.

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