Objective: To optimize molding process of Naodesheng dispersible tablet

and to evaluate its in vitro release. Method: With disintegration time and formability as indexes

kind and ratio of accessories from Naodesheng dispersible tablet were screened by single factor test and orthogonal test;With puerarin as detection index

in vitro release comparative evaluation of Naodesheng dispersible tablet and Naodesheng ordinary tablet was determined by dissolution method. Result: Optimum preparation technology was as follows:with CaSO4 as filler

95% ethanol as adhesive

combined disintegrating agent of 5% microcrystalline cellulose-5% PVPP-5% croscarmellose sodium and 0.5% HPC

hardness of 6-7 kg was suitable for this dispersible tablet;Dissolution rate of Naodesheng dispersible tablet was more than 80% in 10 min and 90% in 15 min

dissolution rate of Naodesheng ordinary tablet was far below 50% within 10 min and less than 80% in 45 min

but dissolution rate of Naodesheng dispersible tablet was 94.65% in 45 min. Conclusion: Preparation process of Naodesheng dispersible tablet was stable

simple and feasible

its in vitro release effect was significantly better than Naodesheng ordinary tablet.