一测多评法测定湿疹软膏中欧前胡素、异欧前胡素的含量

魏凤环; 吴桂欣; 朱清利; 罗扬柱

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一测多评法测定湿疹软膏中欧前胡素、异欧前胡素的含量

更新时间：2024-01-04

- 一测多评法测定湿疹软膏中欧前胡素、异欧前胡素的含量
- Simultaneous Assay of Imperatorin and Isoimperatorin in Shizen Ointment by QAMS
- 中国实验方剂学杂志 2012年18卷第21期页码：125-128
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- 纸质出版日期：2012
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魏凤环, 吴桂欣, 朱清利, 等. 一测多评法测定湿疹软膏中欧前胡素、异欧前胡素的含量[J]. 中国实验方剂学杂志, 2012,18(21):125-128.

WEI Feng-huan, WU Gui-xin, ZHU Qing-li, et al. Simultaneous Assay of Imperatorin and Isoimperatorin in Shizen Ointment by QAMS[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 125-128.
魏凤环, 吴桂欣, 朱清利, 等. 一测多评法测定湿疹软膏中欧前胡素、异欧前胡素的含量[J]. 中国实验方剂学杂志, 2012,18(21):125-128. DOI：

WEI Feng-huan, WU Gui-xin, ZHU Qing-li, et al. Simultaneous Assay of Imperatorin and Isoimperatorin in Shizen Ointment by QAMS[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 125-128. DOI：

摘要

目的: 采用一测多评法测定湿疹软膏中欧前胡素、异欧前胡素的含量

验证一测多评法的适用性。方法: 以欧前胡素为内参物

建立其与异欧前胡素的相对校正因子

考察不同仪器、不同色谱柱对相对校正因子的影响。分别用外标法定量欧前胡素、异欧前胡素的含量

后者与计算值进行比较。结果: 10批湿疹软膏中欧前胡素、异欧前胡素的含量可以用一测多评法进行测定

异欧前胡素含量的计算值与实测值间无显著差异。结论: 该方法以外标法测定欧前胡素

以相对校正因子定量制剂中异欧前胡素的含量是可行的。

Abstract

Objective: To develop a method for simultaneously determining imperatorin and isoimperatorin in Shizen ointment by single marker. Method: Using imperatorin as the internal reference substance

the relative correction factor (RCF) of isoimperatorin was determined by HPLC on different instruments and columns

with good reproducibility. The content of imperatorin in 10 batches of ointment was authentically determined by the external standard method

and the content of isoimperatorin was calculated by external standard method and RCF

respectively. Result: No siginificant differences between the quantitative results of QAMS method and external standard method were observed. Conclusion: QAMS is feasible for determination of imperatorin and isoimperatorin simultaneously

and the developed method can be used for quality control of Shizhen ointment.

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