Objective: To investigate the effects of ultra-micro pulverization on the lignanoid content and dissolution of Schisandra chinensis. Method: QAMS (quantitative analysis multi-components by single marker) was used to determine the content of the lignanoid

and the paddle method was applied to investigate the effects of ultra-micro pulverization on the dissolution of schisandrin. Result: The content of four lignanoids of S. chinensis ultra-micro powder was the same with its fine powder

and the dissolution rate of schisandrin was lower than its fine powder

but their cumulative dissolutions were the same. Conclusion: There was no difference between S. chinensis fine powder and its ultra-micro powder for the content of four lignanoids

including the dissolution of the schisandrin

but the latter dissolution rate was lower.