Objective:The free and total ferulic acid content in dried and fresh Angelica sinensis Radix was measured by HPLC. Method: Free and total ferulic acid content was determined by HPLC. The separation was performed on a ZORBAX Eclipse XDB-C18 column (4.6 mm×250 mm

5 μm) with acetonitrile-0.085% phosphoric acid (17∶83) as mobile phase at temperature of 35 ℃. The flow rate was 1.0 mL·min-1 and the detected wavelength was set at 316 nm; the injection volume was 10 μL. Result: The linear relationship of free and total ferulic acid was excellent within the range of 0.024 2-0.121 0 μg and 0.024 2-0.192 36 μg

and the recovery rates were 96.34% and 97.35%

respectively. The free ferulic acid in dried A. sinensis Radix of 2009 was the highest and the total ferulic acid in fresh A. sinensis Radix was the highest. Conclusion: This method was simple and accurate with good repeatability and stability. It will help to improve the quality control of A. sinensis Radix.