Objective:To study on dynamic change rule of chemical components from Aconitum carmichaelii during decoction process after and before compatibility with Glycyrrhiza uralensis

in order to determine optimum decoction conditions of compatibility of G.uralensis and A. carmichaelii. Method: To determine optimum decoction conditions by determining the contents of total alkaloids and 3 kinds of double ester alkaloid in different decoction time

which were from single decoction liquid of A. carmichaelii and mixed decoction liquid of G.uralensis and A.carmichaelii.And rats cardiac toxicity of soup with optimum boiling technology was investigated. Result: Optimum boiling technology of G. uralensis-A. carmichaelii was:after boiling with a blaze

kept boiling 30 min with small fire.During 0-90 min decoction process

it showed different change trend of the contents of total alkaloids and 3 kinds of double ester alkaloid before and after compatibility of G. uralensis and A. carmichaelii

it reached to both comprehensive peak value in 30 min;both single decoction liquid of A. Carmichaelii and mixed decoction liquid of G. uralensis and A. carmichaelii showed some cardiac toxicity on rats in boiling 30 min

but cardiac toxicity of the latter was relative less. Conclusion: Optimized compatibility boiling technology could provide reference for 'reducing toxicity and storing efficacy’of A. carmichaelii in clinical application and traditional Chinese medicine compound.