Objective:To optimize matrix formulation of Sanhuang Sanyu cataplasm. Method: Taking appearance and adhesion of cataplasm as evaluation indexes

matrix formulation of Sanhuang Sanyu cataplasm was optimized by single factor test and orthogonal test. Result: Optimized matrix formulation of Sanhuang Sanyu cataplasm was NP-700-K90-glycerol(0.5∶0.4∶6).0.02 g·mL-1 solution was received by adding carbomer-u10NF into mixed extraction concentrated liquid of Rheum palmatum and Scutellaria baicalensis

swelling overnight

as A phase

0.5 g sodium polyacrylate and 0.4 g PVP were added to 6 g glycerol as B phase

aluminum chloride and citric acid were added to water as C phase

single extraction concentrated liquid of Phellodendron chinense was as D phase

four phases was fully mixed with A-B-C-D(10∶3∶3∶5)

stirred 15 min

coating

covered with anti-sticking layer. Conclusion: Optimized matrix formulation of Sanhuang Sanyu cataplasm was simple

stable and feasible

which could be applied to industrial production.