CUI Xing-jun, HONG Yan-yan, BI Xue-jie, et al. Influence of Yangzheng Xiaoji Capsule on Expressions of PCNA, P53 and VEGF in Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 304-306.
CUI Xing-jun, HONG Yan-yan, BI Xue-jie, et al. Influence of Yangzheng Xiaoji Capsule on Expressions of PCNA, P53 and VEGF in Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 304-306.DOI:
Objective:To investigate the influence of Yangzheng Xiaoji capsule (YXC) on expressions of Proliferating Cell Nuclear Antigen (PCNA)
P53 protein and vascular endothelial growth factor (VEGF) in gastric cancer tissue. Method: Treatment group was treated by YXC combined with chemotherapy for 6 months. The control group was simply treated by chemotherapy for 6 months. The expressions of PCNA
p53 protein and VEGF were determined by s-p dying
and the data were analyzed by statistics. Result: The expressions of PCNA
P53 Protein and VEGF in the treatment group were lowered compared with those in the controls.They were (33.16±12.6)%
(41.35±11.4)%
(42.16±13.61)% in the treatment group
compared with(63.20±15.3)%
(59.15±11.9)%
(63.19±12.47)% in the controls (P<0.01). Conclusion: YXC inhibits expressions of PCNA
P53 protein and VEGF effectively
and so restrains the malignant appearance of stomach mucosal.