Objective: To observe influence of Jiawei Sini San on serum corticosterone(Cort)

estradiol(E2) content in chronic mild unpredictable stress rats

and reveal the adjustment mechanism of endocrine disorders in female rat depression. Method: Wistar rats were randomly divided into six groups according to the weight and basis for sucrose: control group

model group

Jiawei Sini San high

medium and low dose group (315

158

78 mg ·kg-1

ig)

positive drug fluoxetinegroup (18 mg·kg-1

ig)

stress with every day 8: 30 ig

was performed on the first day control group and model group were ig given distilled water. On 22 day of stress

samples were collected to measure serum Cort

serum E2 content changes by radioimmunoassay in female rats. Result: Serum Cort concent in model group (0.11±0.08) μg·L-1

compared with the control group (0.05±0.04)μg·L-1 was significantly increased(P<0.05). In Jiawei Sini San group cort concentration was lower than in model group

but the difference was not statistically significant. In model group serum E2 levels (0.04±0.02) μg·L-1 compared with control group (0.12±0.03) μg·L-1 decreased significantly (P<0.05).but compared with model group was not significant. In Jiawei Sini San group high

medium and low dose group serum E2 levels (0.10±0.04)

(0.08±0.02)

(0.07±0.05) μg·L-1 were significantly elevated

increased compared with the model group(P<0.01

P<0.05). Conclusion: The antidepressant effect of of Jiawei Sini San may be related to secretion of the E2.