Objective:To investigate the effects of Sanao decoction on allergic airway inflammation in asthma mouse and its component analysis. Method:Sixty BALB/c mice were divide into six groups:normal group

model group

Sanao decoction high

middle

low dose(7.2

3.6

1.8 g·kg-1)

positive group(0.75 mg·kg-1)

mice in each group (except those in the normal group) were sensitized with 0.2 mL sensitized solution (OH)3] during the period from 15 to 28 day

and given corresponding drugs 30 min later

mice were atomized with 5% OVA; mice in normal group were sensitized with physiological saline and were atomized with physiological saline . Samples ofblood were collected for counting numbers of eosinophilic granulocyte(EOS)

and broncho alveolar laverge fluid(BALF)was colledted for counting inflammatory cells. UPLC-TOFMS was used to analyze its chemical compositions. Result:Sanao decoction could obviously reduce numbers of EOS (P<0.01

P<0.05)

in blood and BALF(P<0.05

P<0.01) and 22 compounds in Sanao decoction could be identified. Conclusion:Sanao decoction can obviously inhibit allergic airway inflammation in asthma mouse

22 compounds which are related to effect of Sanao decoction are belong to alkaloids

flavonoids

saponins.