Objective: To explore effect of combination of Aidi injection and neoadjuvant chemotherapy on patients with non-small-cell lung cancer and number of CD4+CD25+ T regulatory cells (NSCLC). Method: Fifty patients with NSCLC were chosen for this research. Patients were divided into control group of 20 patients without application of Aidi injection and treatment group of 35 patients applied with Aidi injection. The following indexes like their short-term curative effect

operation time

blood loss in operations

ablation rate and side effects were observed;flow cytometry was used to detect and compare number of Treg before and after treatments. Result: Compared with control group

blood loss in operation was decreased significantly (615.49±114.08)mL vs.(530.15±104.55)mL (P<0.05)

curative effect increased significantly (30.00% vs 45.71%) (P<0.05)

and occurrence of leucopenia decreased significantly (60.00% vs 37.14%) (P<0.05). Number of Treg was decreased significantly after treatments for all patients (P<0.05)

which was more significant in treatment group than in control group (P<0.05). Conclusion: Combination of Aidi injection and neoadjuvant chemotherapy can enhance clinical effects on patients with NSCLC

meanwhile enhance tumor immunity and reduce side effect during the treatment.