Objective:To study Disporum sessile's effects of anti-cough and anti-sputum. Method:Mice were randomly divided into 6 groups:blank

positive medicine

ethyl acetate layer high

low doses (2.5

1.25 g·kg-1) and water layer high

low doses (2.5

1.25 g·kg-1). Drugs were ig administrated for 5 days. Cough caused by strong ammonia in mice was used to evaluate anti-cough effect. Phenol red applied to trachea in mice was used to observe the efficacy of anti-sputum. Trachea clips isolated from rabbit were randomly divided into groups:positive medicine

ethyl acetate layer low

medium

high doses (100

10

1.0 g·L-1) and water layer high

medium

low doses (100

10

1.0 g·L-1). The model of cilia movement was applied to observe the efficacy of promotion of cilia movement. Result:The ethyl acetate layer showed significant anti-cough effect(P＜0.01). The phenol red concentration of the water layer was higher than that of the ethyl acetate layerwith no significant difference. High concentration of the ethyl acetate layer and the water layer could obviously quicken the speed of the rabbit's cilia movement. Conclusion:The acetate layer and the water layer extract of Disporum sessile has the effects of anti-cough and anti-sputum.The herb's active ingredients of anti-cough effect mainly exists in ethyl acetate layer.