Objective:To study the antifatigue effect of Pingwei San(PWS) on rats of the spleen and stomach being stranded by dampness. Method: Rat models of the spleen and stomach being stranded by dampness was made. The rats were divided randomly into five groups: the control group

the model group and three groups administered with high

mediate and low dose of respectively. at the eighth day after modeling

the control group and the model group were administrated with physiological saline solution

the others three groups were administered with 1.5

3

6 g·kg-1 PRFS respectively. After final administrating

the behavioral changes of rats were observed and the exhaustive swimming time of rats was recorded. At the end of the experiment

the levels of blood plasma lactic acid(LA)

serum lactate dehydrogenass(SLDH)

serum urea nitrogen(SUN)

hepatic glycogen

and hemoglobin(Hb) were determined. Result: The rat behaviors in the three groups with PWS were remarkably improved. The last exhaustive swimming time increased significantly

hepatic glycogen level of high-dose group rats was obviously increased(P<0.01)

and SUN level of high-dose and mediate-dose group rats were decreased significantly(P<0.05). The levels of Hb

LA and SLDH in all animals were not different obviously. Conclusion: Decreasing disintegration of protein and amino acids

and increasing the level of hepatic glycogen in exercise load were possibly antifatigue mechanism of PWS.