Objective:To evaluate clinical efficacy of Kangfuxin liquid in the treament of hand-foot-mouth disease. Method: Literatures were retrieved from Cochrane library

PubMed

CNKI

VIP

WanFang.and Meta-analysis was performed. Result: Fourteen RCTs and 1 792 patients were included.The meta-analysis showed that Kangfuxin liquid-treated group was better than control group in terms of defervescence time

oral herpes or ulcer improvement time

the skin rash regression time and the total clinical efficacy.Serious adverse drug reactions(ADRs) induced by Kangfuxin liquid hadn't been reported. Conclusion: Actual clinical evidence indicated that efficacy and safety of Kangfuxin liquid in the treament of Hand-Foot-Mouth Disease.The reliability of systematic review is affected by low quality of included study.More randomized controlled trial of high-quality large-scale multiple-centered should be carried out.