Objective:To observe the effect of Kangxin decoction on regulating vitamin D in rats with myocardial hypertrophy induced by isoproterenol. Method:Fifty male SD rats were randomly divided into 5 groups:normal group

model group

three dose groups of Kangxin decoction (10

5

2.5 g·kg-1). Myocardial hypertrophy model in rats was induced by subcutaneous injection of isoproterenol (ISO

2.4 mg·kg-1

7 d). After Kangxin Decoction intervention for 6 weeks

serum 25(OH) D3

atrial natriuretic peptide (ANP)

renin were detected by ELISA. Pathological changes in myocardial tissue were determined by hematoxylin-eosin (HE) staining. Result:Compared with the controls

serum 25(OH) D3 in the model group was reduced

and serum ANP and renin were elevated (P<0.05).Myocardium derangement and fibrotic hyperplasia were also seen in the models. After Kangxin decoction treatment

serum 25(OH) D3 was increased

accompanied with lower ANP and rennin. The degree of myocardial fibrosis was improved after the treatment. Conclusion:Kangxin decoction had an effective role to treat myocardial hypertrophy induced by ISO by regulationg vitamin D and protecting myocardial cells from injury.