Objective: To optimize the formulation and process development of Trollius chinensis dispersible tablets. Method: With the amount of microcrystalline cellulose (A)

low replace hydroxypropyl cellulose (B)

crosslinking povidone (C) and aerosol(D) as the influencing factors and the disintegrating time taken as index

the formula of Trollius chinensis dispersible tablets was optimized by orthogonal experiment; the content determination was done by HPLC. Result: The optimized formula was A3B2C3D3.The contents of A

B

C and D were 30%

5%

8% and 8%

respectively. The products formulated by the optimum techniques were bright and clean

the average disintegration time was 80 s with good distribution homogeneity. The content of orientin was 16.02 mg/piece and the dissolution quantity achieved 90% above in 15 min. Conclusion: The dispersible tablets prepared in this study are better and have a good distribution homogeneity

it can reach the design standard.