Objective:To discuss influence of oven baking on double and single ester type alkaloids from Aconitum carmichaeli. Method:A. carmichaeli were processed as follows:cut into slices→protect color→hot drift→baking

with the content of double and single ester type alkaloids as evaluation indexes

orthogonal test was used to investigate influence of hot drift time

baking temperature

baking time on the content of two type alkaloids. Result:With increase of each factor level

the content of double ester type alkaloids decreased

but the content of single ester type alkaloids increased.In addition

the content of single ester type alkaloids in ten products met requirements of the ‘Chinese Pharmacopoeia' of black slice

white slice

and dan slice

the content of double ester type alkaloids in six products met requirements of the ‘Chinese Pharmacopoeia' of sold black slice and white slice. Conclusion:The content of double and single ester type alkaloids could met limited requirements of the 2010 edition ‘Chinese Pharmacopoeia' by oven baking.