Objective: To observe the effect of Junzi Fuzheng decoction in enhancing anti-tumor efficacy of cyclophosphamide and reducing its toxicity. Method: Fifty MFC bearing mice models were established and then divided randomly into five groups: control group

cyclophosphamide(CTX) group(30 mg·kg-1)

Junzi Fuzheng decoction (high

medium and low dose

20

10

5 g·kg-1) combined with CTX(30 mg·kg-1)groups.There were 10 mice in each group. After 10 days of treatment

all mice were killed and the tumor inhibiting rates and the index of immunological function were observed. Result: The tumor inhibition rate was higher in each Junzi Fuzheng decoction+CTX group than that in control group (P <0.01).The tumor inhibition rate of high-dose and medium-dose Junzi Fuzheng decoction+CTX group was higher than that in CTX group (P <0.01

P <0.05).The indexes of spleen and thymus as well as proliferation of T lymphocytes and nature killer cell activity in CTX group were lower than those in the high-dose Junzi Fuzheng decoction+CTX group (P <0.01

P <0.05).The counting of peripheral white blood cells and bone marrow nucleated cells in CTX group was lower than those in the high-dose and the medium-dose Junzi Fuzheng decoction+CTX groups (P <0.01

P ＜0.05). Conclusion: Junzi Fuzheng decoction can enhance the efficacy of chemotherapy and reduce its toxicity in the MFC-burdened mice exposed to CTX.