Objective: To evaluate the effect of Levam Lodipine and Salvia Miltiorrhiza Freeze-dried powder injection combination on in-stentrestenosis after intracoronary stenting. Method: Two hundreds and Twenty-two coronary heart disease patients with successful intracoronary stenting were divided randomly into the control group

the group of Salvia Miltiorrhiza Freeze-dried powder injection

the group of Levam Lodipine and the group of combination (Levam Lodipine plus Salvia Miltiorrhiza Freeze-dried powder injection). Coronary angiograhpic(CAG) was made in patients with the angiograms of post-intervention and 6 months after treatment for all group. And serum(endothelin) ET

(nitrogen monoxide)NO

(triglycerid)TG and(serum total cholestero)TC were detected in patients with the angiograms of post-intervention and 6 months after treatment for all group. Result: In-stent restenosis (ISR) rate was significant decreased in the group of combination(P<0.05). The serum TC and TG levels were decreased in the group of Salvia Miltiorrhiza Freeze-dried powder injection

the group of Levam Lodipine and the group of combination. The serum ET level was decreased in the group of Levam Lodipine and the group of combination

while the NO levels was increased(P<0.05). Conclusion: Both Salvia Miltiorrhiza Freeze-dried powder injection and Levam Lodipine has benefit for preventing restenosis after intracoronary stenting.