Objective:To explore effective way to optimize the proportion of effective components from Panax notoginseng and Crataegus pinnatifida Bge. Method:According to table U6(64) in uniform design

mice were divided into 6 treatment groups

the ratios between flavonoids of Crataeguspinnatifida and total saponins of P. notoginseng were 200:15

100:1.875

50:30

25:3.75

12.5:60

6.25:7.5(mg·kg-1)accordingly. The treatments lasted for 5 days. Then

survival time of mice were evaluated by two models

isoproterenol injection intraperitoneally and acute cerebral ischemia induced by broken neck. The best proportion of effective components was calculated by multiple regression equations. Result:The best ratio appeared to be 20:15 mg·kg-1

namely

the ratio of 4:3.The proportion could prolong the survival time of mice with acute cerebral ischemia (P＜0.05). Conclusion:The combination of uniform design and animal models in pharmacodynamics is an effective way to optimize the proportion of Chinese medicinal components.