Objective: To explore application of Xuebijing in treatment of severe pneumonia and its effects on inflammatory factors and cellular immunity. Method: Fifty patients were chosen with severe pneumonia divided them into control group and treatment group receiving basic treatment including anti-infection

nutritional support

and mechanic ventilation and so on. Treatment group received an additional treatment of Xuebijing Injection during the treatment. Result: Compared with control group

the total effective rate in treatment group was increased significantly (84.00% vs 96.00%) (P＜0.05); serum level of interleukin-1(IL-1)

interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) decreased significantly after treatment (P＜0.05)

a more significant decrease was found in treatment group than in control group (P＜0.05); compared with control group

CD4+/CD8+ ratio increased significantly after treatment (P＜0.05). Conclusion: Application of Xuebijing based on regular therapy shows a fine effect in treatment of severe pneumonia by decreasing inflammatory level and increasing cellular immunity.