Objective:To investigate effect of different boiling conditions on quality of Buyang Huanwu decoction by high-pressure decoction machine

and optimize boiling process. Method:With total solid content

the content of ferulic acid and astragaloside as indexes

orthogonal test was used to analyze effect of four factors including soaking time

the amount of water

boiling time and boiling temperature.The content of ferulic acid and astragaloside were determined by HPLC. Result:Orthogonal test analysis of variance showed that order of influence factors:the amount of water>boiling temperature>soaking time>decoction time

none of these factors had significant impact on extraction technology.Optimum boiling technology of Buyang Huanwu decoction was:medicinal pieces soaked 30 min with 12 times the amount of water

decoction time 60 min

boiling temperature of 120℃. Conclusion:This optimized technology and technical parameters provided theoretical basis for traditional Chinese medicine decoction with ferulic acid and astragaloside as main ingredients

which was prepared by high-pressure decoction machine.