Objective:To investigate the effects and mechanism of anger stress on behavior and memory in the D-gal induced brain aging model rats. Method:Wistar rats were randomly divided into control group

anger model group

D-gal group

anger+D-gal group

and attack rats. The D-galgroup and anger+D-gal group were administered ip 1% D-gal physiological salinesolution(PSS) 10 mL·kg-1·d-1. The control group and anger model group were ip given the same volume of PSS for 6 weeks. From the third weeks

the anger model group and anger+D-gal group accepted the anger stimulation test for 4 weeks. Each rat in anger model group was placed into one cage and accepted the attack from the invade rat

the tail of invade rat was clamped by using haemostat packed with bandage

two rats bite each other 20 min per day. Morris water maze test was carried out in the 37 days. Six days later all rats were executed and the brain tissue was collected for measurement of superoxide dismutase(SOD)

malondialdehyde(MDA)

lipofuscin (LPF)

meanwhile

pathological changes were observed on cerebral cortex and seahorse. Result:Compared with control group

the behavior and memory significantly decreased(P<0.05

P<0.01)

the brain tissue SOD activity wassignificantly reduced (P<0.01) and MDA

LPF content were obviously increased (P<0.01) in the anger model group

D-gal group and anger+D-gal group. Furthermore

pathological study showed that the cerebral cortex and seahorsein in the anger model group

D-gal group and anger+D-gal group appeared pathological changes compared with control group

the pathological changes in anger+D-gal group were most obvious. Conclusion:The anger stress has the negatively effects on behavior and memory in the D-gal induced brain aging model rats.