Objective:To evaluate the effect of 4-methyl-cyclopentadekanone on learning and memory in vascular dementia rats. Method: Ninty rats were divided randomly into positive control group(6.1 mg·kg-1)

model group

sham operation group

4-methyl-cyclopentadekanone low

medium and high dose group(8.1

2.7

0.9 mg·kg-1). The model was indueced by arteria carotis ligation

and after 7 days these rats were administrated orally once a day for 28 days and given a administration dose at 10 mL·kg-1.The model group and sham operation group were administrated normal saline. Related biochemical indicators and praxiology in each group were observed. Result: Avoiding dark counts and total cholinesterase(TChE) activity degrade obviously(P＜0.05)while the intragastric administration was 8.1

2.7 mg·kg-1

meanwhile the SOD activity increase at a dose of 8.1 mg·kg-1. Conclusion: 4-methyl-cyclopentadekanone can enhance learning and memory in vascular dementia rats.