Objective: To observe the influence of Astragali Radix and Angelicae Sinensis Radix on level of interferon-γ (IFN-γ) and interleukin-4(IL-4) in serum and expression of signal transducers and activators of transcription 6(STAT6)

signal transducers and activators of transcription 4(STAT4) of airway allergic inflammation in rats

in order to partly show the mechanism of Astragali Radix and Angelicae Sinensis Radix in treating airway allergic inflammation. Method: The model of airway allergic inflammation in rats were caused by OVA. Astragali Radix and Angelicae Sinensis Radix were used to control the model rats. The contents of IFN-γ and IL-4 in the serum were detected by ELISA. The expression of STAT6

STAT4 in lung tissue were detected by Western blot. Result: The level of IL-4 in serum of model group were significantly higher than those in the control group. The level of IFN-γ in serum of model group were significantly lower than those inthe control group. Astragali Radix can depress the level of IL-4 in serum

and increase the level of IFN-γ in serum. Angelica can depress the level of IL-4 in serum. Compatibility of Astragali Radix and Angelicae Sinensis Radix can depress the level of IL-4 in serum

and increase the level of IFN-γ in serum. Astragali Radix can depress the expression of STAT6

p-STAT6 in lung tissue

and increase the expression of p-STAT4.Angelicae Sinensis Radix can depress the expression of p-STAT6.Compatibility of Astragali Radix and Angelicae Sinensis Radix can depress the expression of STAT6

p-STAT6 in lung tissue

and increase the expression of STAT4

p-STAT4. Conclusion: Compatibility of Astragali Radix and Angelicae Sinensis Radix may adjust the balance of Th1 and Th2 by restaining STAT6 and promoting STAT4 to control the airway allergic inflammation.