Objective:To study the antiallergic action of Shuningkang by investigating the effect of aqueous extract from Shuningkang on mast cell degranulation and histamin releasing in vitro by PMC degranulation percentage and histamine releasing assay. Method:OVA was used as allergen. In the concentration of 40 mg·L-1

30 min conditions

the influences of aqueous extract from Shuningkang 0.1

1

10 g·L-1on sensitized rat mast cell degranulation and histamine release were investigated. Result:The extract of Shuningkang could inhibit rat PMC degranulation and histamine releasing in vitro. PMC degranulation rates in model group

high

middle

low does groups of Shuningkang and Cromoglicate Sodium group were (47.53±5.57)%

(25.11±2.56)%

(35.71±6.99)%

(47.11±4.26)% and(22.87±6.52)% respectively. Shuningkang showed significant inhibition on histamine release

compared with the model group. In the high

middle

low does groups of Shuningkang and Cromoglicate Sodium group

the inhibition rates on histamine release were 16.85%

20.06%

6.58%

16.85%. Conclusion:Shuningkang has certain effect on skin allergies.