Objective:To study the effects of Fufang Ejiao Jiang (FFEJJ) against 5-fluorouracil (5-FU) chemotherapy in hepatoma H22-hearing mice. Method: The SPF-Kunming mice were used to establish mouse model of hepatoma H22.The mice were randomly divided into 5 groups: tumor model group

5-FU group (20 mg·kg-1

ip)

5-FU combined FFEJJ group. FFEJJ were orally administrated at a daily dose of 3

1.5

0.75 g·kg-1

respectively corresponding to high

middle and low dose. The normal control group was set up and each group had 10 mice. After continuous administration for 7 d

the peripheral white blood cell count (WBC)

tumor weight

inhibition rate

spleen index and thymus index were measured. The peripheral blood lymphocyte transformation rate and the phagocytotic activity of peritoneal macrophages were detected. Result: The high-dose FFEJJ significantly reduced the tumor weight

elevated the spleen index

thymus index and WBC counts compared with 5-FU group (P＜0.05). 5-FU decreased the lymphocyte transformation rate and peritoneal macrophage phagocytosis rate and the phagocytic index(P＜0.01). These index in FFEJJ group were significantly higher than that of 5-FU group (P＜0.05)

and reached to (35.9±9.2)%

(41.9±6.3)%

and (0.74±0.17) in high dose FFEJJ group respectively. Conclusion: The results suggest that FFEJJ could enhance efficacy and reduce toxicity in hepatoma treatment as a supplement of 5-FU.