Objective: Using rat intravenous endotoxin model of fever to observe the antifebrile effect of Maxing Shigan Tang. Method: the effects of Maxing Shigan Tang on body temperature was observed on the fever induced by intravenous injection of lipopolysaccharide(LPS) at the dose 5

10

20

40

60

80 μg · kg-1

respectively. The rats were randomly divided into blank group

model group

treatment group (low

medium and high dose respectively 1.33

4.5

15.2 g · kg-1)

the model was induced immediately after administration. Result: Intravenous injection of endotoxin could increase body temperature significantly (P<0.01). The results showed that the dose of intravenous injection of endotoxin induced SD rat fever model was 20 μg · kg-1. The body temperature was significantly lower compared with model group after fed with low

medium and high dose of Maxing Shigan Tang (P<0.05). TRI showed a clear dose-response relationship. Conclusion: Maxing Shigan Tang has a better antifebrile effects on the fever induced by intravenous injection of LPS in rats

and show a dose-dependent manner.