Objective: To optimize extraction technology of Salvia miltiorrhiza. Method: With the content of salvianolic acid B

total salvianolic acid

tanshinoneⅡA

total tanshinone as indexes

the content of index ingredients were determined by HPLC

UV spectrophotometry and colorimetry

ethanol refluxing extraction technology was optimized by orthogonal test with taking the concentration of ethanol

extraction time

the amount of ethanol

size of material and extraction times as factors. Result: Optimum extraction technology was:S. miltiorrhiza was cut into sections

extracted 3 times with 10 folds the amount of 60% ethanol

2 hours each time. Conclusion: Extraction rate of water-soluble and fat-soluble constituents from S. miltiorrhiza was high by optimized technology

and it was stable and energy-saving.