Objective:To optimize alcohol extraction technology of total flavonoids from Zhichen Weili tablet. Method: With content and pharmacodynamic effect of total flavonoid as indexes

extraction solvent was determined by single factor test;With the content of naringin

hesperidin and neohesperidin as comprehensive scoring index

the concentration and amount of ethanol

extraction time and extraction times were chosen as factors

alcohol extraction technology of total flavonoids from Zhichen Weili tablet was optimized by orthogonal test. Result: Optimized alcohol extraction conditions were:reflux extracted 3 times with 7

6

6 times the amount of 70% ethanol

extracted 2 h per time. Conclusion: This extraction process was reasonable and simple

it could provide a reference for production process of total flavonoids from Zhichen Weili tablet.